The BrainPower™ Fomulation consists of four components which are extremely important in preventing, repairing, and enhancing brain function. They are acemannan, nicotinamide riboside (NR), curcumin and vitamin B12.  Each of these supplements is encapsulated in what we call NutraNanoSpheres™, which are about one thousand times smaller in diameter that a human red cell. This small size assures a bioavailability of greater than 10 fold regardless of the encapsulated component.  Besides the high bioavailability, the NutraNanoSpheres™ comprising each of these four natural ingedients are water soluble drops, which do not break down in the stomach or intestines, travel directly into the bloodstream and through the blood-brain barrier to intiate their beneficial effects to the brain. 

Acemannan (Polymannose)

Alzheimer’s disease is the sixth-leading cause of death in the U.S. and is the only one among the top 10 killers of Americans that has no cure or preventive measure, nor can be delayed (Alzheimer’s Association -2012).  Lewis, et al. (2013) used polymannose (acemannan) alone to significantly improve the cognitive response rate in 17/34 Alzheimer’s patients.   Furthermore the polymannose increased the pleuripotent stem cell activity of these patients, which would positively increase the production of new neurons in the brain (Sweeney, et al. 2002).  In fact,  cognitive issues may be due to a nutritional deficiency of polymannose in the diet. Supplementation as described here and consuming foods rich in polymannose, such as broccoli, may aid in the prevention and treatment. The recommended daily intake is about 29 mg (Bialoe by Lorand Labs.com).

Nicotinamide riboside

Nicotinamide adenine dinucleotide (NAD)+, a coenzyme involved in redox activities in the mitochondrial nicotinamide riboside (NR) electron transport chain, has been identified as a key regulator in the life-span extending effects.  The activation of NAD+ expression has been linked with a decrease in beta amyloid (Aβ) toxicity in Alzheimer’s disease (AD).  NR is a NAD+precursor, it promotes peroxisome proliferator-activated receptor-γ coactivator 1 (PGC)-1αexpression in the brain. Evidence has shown that PGC-1α is a crucial regulator of Aβ generation, because it affects β-secretase (BACE1) degradation. Therefore NR actually reverses the formation of plaque in the brain resulting in cognitive function of the hippocampal areas of the brain that are responsible for the assembly of short-term memory (Gong, et al. 2013). Additional studies with NR in models of Alzheimer's disease indicate bioavailability to brain and protective effects, likely by the stimulation of brain NAD synthesis Chi and Sauve 2013). The daily recommended dosage of 100 mg daily is recommended by Life Extension and others.

Curcumin

Curcumin, which is found in the spice turmeric (curry), is noted for brain health. It has been shown to be effective in stopping protein clumping that is the first step in diseases such as Parkinson’s disease.  Furthermore, it also may inhibit the accumulation of destructive beta amyloids in the brain of Alzheimer patients.  Curcumin can pass the blood-brain barrier and also shown a powerful antioxidant and anti-inflammatory response (Morales, et al. 2014).

Dementia, a serious loss of global cognitive ability including the impairments of memory, attention, language, and problem solving, is continually growing worldwide as the elderly population increases. There are approximately 35.6 million people with dementia worldwide (Prince, et al. 2013).    Due to the rapid growth of dementia, high expenditure cost, and unsatisfactory outcomes of therapeutic strategy, dementia has been recognized as one of the major medical and social challenges especially in developing Countries (Brookmeyer, et al. 2007).   Recent findings have shown that the age-related cognitive dysfunction occurs as a result of oxidative stress elevation in the brain (Mattson 2004), hippocampal atrophy Wolf, et al. 2001), and the disturbances of neurotransmission, especially cholinergic transmission. Therefore, the modulation of cholinergic function becomes the approach to dementia treatment. However, most drugs still induce adverse effects (Doggrell and Evans 2003).  This disadvantage consequently motivates research effort to find out novel protective agent against dementia. Herbal medicine has long been used to treat numerous ailments. Moreover, the “Green” movement has driven attitude changes of the general population to prefer naturally derived substances and extracts as being inherently safer and more desirable than synthetic chemical products. Accumulative lines of evidence have demonstrated that consumption of antioxidant-rich foods and polyphenol treatment using curcumin can enhance cognitive performance in elderly subjects (Valls-Pedret, et al. 2012; Ataie, et al. 2010; Craggs and Kalaria  2011; Morales, et al.  2014; Chojnacki, et al. 2014).  The recommended daily intake of curcumin is about 100 mg daily.

Vitamin B12

A Finnish study in the Journal of Neurology has shown diets rich in B12 may reduce the risk of Alzheimer’s disease years later.   In fact, increased levels of vitamin B12 has been used to treat the disease (Engelborghs, et al. 2014).  The recommended daily dosage is 5,000 mcg (ug).

References

Ataie, A., Sabetkasaei, M., Haghparast, A., Moghaddam, A. H., and Kazeminejad, B. (2010). Neuroprotective effects of the polyphenolic antioxidant agent,Curcumin, against homocysteine-induced cognitive impairment and oxidative stress in the rat.  Pharmacology Biochemistry and Behavior.  96:378–385.  PMID: 20619287

Brookmeyer R., Johnson E., Ziegler-Graham K., and Arrighi H. M. (2007) Forecasting the global burden of Alzheimer’s disease. Alzheimer’s and Dementia.  3:186–191. PMID: 19595937

Chi,Y , Sauve, AA. Nico  (2013). Nicotinamide riboside, a trace nutrient in foods, is a vitamin B3 with effects on energy metabolism and neuroprotection.  Curr. Opin. Clin. Nutr Metab Care.16: 657-61. PMID: 24071780

Craggs. L. and R. N. Kalaria (2011) Revisiting dietary antioxidants, neurodegeneration and dementia.  NeuroReport.  22:1–3. PMID: 21127442

Doggrell S. A. and Evans S. (2003) Treatment of dementia with neurotransmission Modulation. Expert Opinion on Investigational Drugs.  12:1633–1654. PMID: 14519085

Gong, B. et al. (2013) Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer’s mouse models. Neurobiol Aging. 34: 1581-1588 PMID: 23312803

Alzheimer’s Association (2012) Alzheimer’s disease facts and figures. Alzheimers Dement 8, 131-168. Link to PDF

Jernerén F, Elshorbagy AK, Oulhaj A, Smith SM, Refsum H, Smith AD (2015) Brain atrophy in cognitively impaired elderly: the importance of long-chain ω-3 fatty acids and B vitamin status in a randomized controlled trial. Am J Clin Nutr. Ajcn 103283 [Epub ahead of print] PMID: 25877495

Lewis, JE et al.  (2013) The effect of an aloe polymannose multinutrient complex on cognitive and immune functioning in Alzheimer’s disease. J Alzheimer’s Disease. 33:393-406. PMID: 22976077

Mattson M. P. (2004) Pathways towards and away from Alzheimer’s Disease.  Nature.  430: 631–639. PMID: 15295589

Prince M., Bryce R., Albanese E., Wimo A., Ribeiro W., and Ferri C. P. (2013).  The global prevalence of dementia: a systematic review and meta analysis.  Alzheimer’s Dementia.  9: 63–75. PMID: 23305823

Remington, R. et al.(2015). A phase II randomized clinical trial of a nutritional formulation for cognition and mood in Alzheimer's disease. Journal of Alzheimer's Disease, 45(2), 395-405. PMID: 25589719

Sweeney EA, Lortat-Jacob H, Priestley GV, Nakamoto B, Papayannopoulou T (2002) Sulfated polysaccharides increase plasma levels of SDF-1 in monkeys and mice: Involvement in mobilization of stem/progenitor cells. Blood 99, 44-51. PMID: 11756151

Wolf H., Grunwald M., Kruggel F., et al. (2001) Hippocampal volume discriminates between normal cognition; questionable and mild dementia in the elderly.  Neurobiology of Aging.  22:  177–186. PMID: 11182467

Valls-Pedret C., R. M. Lamuela-Ravent´os, A. Medina-Rem´on et al. (2012) Polyphenol-rich foods in the Mediterranean diet are associated with better cognitive function in elderly subjects at high cardiovascular risk.  Journal of Alzheimer’s Disease.  29: 773–782. PMID: 22349682

BrainPower Package Insert: download